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Evidence strength: Strong for Thymosin Beta-4 based on Phase 3 trial

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[DOI] [PubMed] [Google Scholar] 98.Skovlund E, Handal M, Selmer R, Brandlistuen RE, Skurtveit S

In addition, when co-cultured with human breast cancer cells, neutrophils produced high levels of oncostatin M (OSM) (84), which was shown to act on the endothelium via STAT-3/VEGF signaling in vivo and to enable the remodeling of the TME by activating cancer-associated fibroblasts (CAF) (85, 86)